یک مدل یکپارچه برنامه‌ریزی ریاضی تولید و توزیع رادیو داروها (مطالعه موردی: شرکت پارس ایزوتوپ)

نوع مقاله : پژوهشی

نویسندگان

1 دانشگاه علم و فناوری مازندران، بهشهر، ایران

2 عضو هیئت علمی دانشگاه علم و فناوری مازندران

3 استادیار گروه مهندسی صنایع دانشکده مهندسی شیمی و صنایع، دانشگاه علم و فناوری مازندران، بهشهر، ایران.

چکیده

با توجه به افزایش روزافزون مرگ‌ومیرهای ناشی از بیماری سرطان، اهمیت تولید رادیو داروها افزایش می‌یابد. رادیو داروها در فرآیند تشخیص سرطان، ارزیابی عملکرد بافت بدن و همچنین در فرآیند درمان مورداستفاده قرار می‌گیرند. یکی از مشخصه‌های حیاتی رادیو داروها نیمه‌عمر بسیار کوتاه و کاهش سریع اثر آن است. این مسئله مبین ضرورت برنامه‌ریزی هم‌زمان تولید و توزیع است. در این مقاله باهدف افزایش سودآوری تولید، یک مدل برنامه‌ریزی ریاضی یکپارچه جهت برنامه‌ریزی تولید، توزیع و تزریق رادیو دارو ارائه‌شده است. مدل پیشنهادی سعی می‌نماید تا با کاهش فاصله زمانی از تولید تا تزریق، هزینه‌های تولید که وابسته به مدت‌زمان بمباران مواد اولیه در فرآیند تولید است را کمینه نماید. به‌منظور نزدیک‌تر شدن مدل پیشنهادی به شرایط دنیای واقعی، برای هر سفارش مشتری یک پنجره زمانی متناسب با حداکثر میزان تأثیرگذاری رادیو دارو در نظر گرفته‌شده است. اعتبار و کارایی مدل پیشنهادی از طریق پیاده‌سازی در یک مطالعه موردی مورد تحلیل قرار گرفت. نتایج نشان می‌دهند که مدل یکپارچه برنامه‌ریزی تولید و توزیع نه‌تنها می‌تواند از هزینه‌های تولید بکاهد بلکه با تحویل به‌موقع در پنجره زمانی مشتریان اثرپذیری رادیو دارو و رضایت مشتریان را افزایش دهد.

کلیدواژه‌ها

عنوان مقاله [English]

An integrated mathematical model of production and distribution planning for radiopharmaceutical products (Case study: Pars isotope company)

نویسندگان [English]

  • mohsen radmehr 1
  • hadi Abdollahzadeh Sangroudi 2
  • Navid Sahebjamnia 3
1 M.S. Student of Industrial Engineering, Department of Chemical and Industrial Engineering, Mazandaran University of Science and Technology, Behshahr
2 Faculty of Chemical and Industrial Engineering, Mazandaran University of Science and Technology, Behshahr, Iran,
3 Assistant Professor of Industrial Engineering Department of Chemical and Industrial Engineering, Mazandaran University of Science and Technology, Behshahr, Iran
چکیده [English]

Production and Distribution planning of radiopharmaceutical products aroused as a major concern due to the increasing the number of cancer patients and deaths. Radiopharmaceuticals are not only used for diagnosing process but also utilized for evaluating the function of body tissue and treatment. Shorter half-life of the radiopharmaceutical products rather than deteriorated products have complicated its production and distribution decision problems. In this paper an integrated mathematical programming has been developed for optimizing production, distribution, and injection planning of the radiopharmaceutical products. The proposed model aims to maximize production profitability through decreasing the production costs. Also the trade-off between production cost (depend on the time it takes to bombard raw materials) and the deviation time between production and injection times have been considered according to the nature of radiopharmaceutical production process in real-world problems. Furthermore an injection time window is considered for customer shown the preference of the customer to receive the radiopharmaceutical. The validity and efficiency of the proposed model were analyzed by implementation in a case study. The results show that the integrated model of production and distribution planning can not only decrease the cost of production but also increase the satisfaction level of the customers.

کلیدواژه‌ها [English]

  • Integrated production and distribution programming
  • Radiopharmaceuticals
  • Short half-life products
  • Mix Integer Programming
  • Deterioration rate

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مدیریت زنجیره تأمین
دوره 22، شماره 67
شهریور 1399
صفحه 80-92

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سابقه مقاله

  • تاریخ دریافت: 20 اردیبهشت 1399
  • تاریخ بازنگری: 01 مرداد 1399
  • تاریخ پذیرش: 21 مرداد 1399

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